MersV1, France, Analysis, bibRecord, 000336

Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins

Identifieur interne : 000336 ( France/Analysis ); précédent : 000335; suivant : 000337

Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins

Auteurs : Michèle Ernoult-Lange [France] ; Valérie Arranz [France] ; Maryvonne Le Coniat [France] ; Roland Berger [France] ; Michel Kress [France]

Source :

Journal of Molecular Evolution [ 0022-2844 ] ; 1995-12-01.

RBID : ISTEX:CE4CFD3539F638C3DCAAB09B6CAAA5B7EB564D41

English descriptors

KwdEn :
- Chromosome location, Divergent evolution, Human, Mouse, Zinc-finger protein.
Teeft :
- Acidic, Additional motifs, Amino, Amino acids, Bellefroid, Biol, Blot, Cdna, Cdna1, Cell lines, Chromosome, Clone, Coding, Coding region, Codon, Corresponding mouse sequence, Different lanes, Different reading frames, Different restriction endonucleases, Encodes, Exon, Finger region, First motif, Gene, Genome, Genomic, Ghsmokcll, Ghsmokcll genomic clone, Hela, High stringency, Homology, Hsmok2, Human chromosome, Human gene, Human genomic, Human genomic ghsmokcll clone, Human mok2 gene, Human mok2 protein, Human protein, Hybridization, Hybridized, Mok2, Mok2 cdna, Mok2 gene, Mok2 protein, Mok2 transcripts, Motif, Mouse mok2 gene, Mouse mok2 protein, Mrna, Murine, Murine genomic, Murine mok2 cdna, Murine mok2 gene, Murine mok2 protein, Murine protein, Murine sequence, Nonfinger, Nonfinger coding region, Nucleic acids, Nucleotide, Nucleotide sequence, Nucleotide sequences, Proc natl acad, Single copy, Southern analysis, Southern blot, Stringency, Strong identity, Structural features, Transcription, Untranslated, Untranslated exon, Untranslated sequence, Xenopus, Xenopus laevis.

Abstract

Abstract: We have isolated the human homologue of Mok2 gene encoding a Kriippel-like protein. The identification of three cDNAs and genomic clones reveals that the human protein shows substantial structural differences with the mouse MOK2 protein. The mouse MOK2 protein is composed of seven tandem zinc-finger motifs with five additional amino acids at the COOH-terminal. This structural feature is also present at the end of the human MOK2 protein. The seven zinc-finger motifs show 94% identity between the two proteins. In addition, the human protein contains three additional zinc-finger motifs in tandem with the others and a nonfinger acidic domain of 173 amino acids at the NH2-terminal. The Southern analysis indicates that a single copy of these two genes is present in the genome. The human gene has been localized on chromosome 19 on band q13.2–q13.3. The comparison of human and mouse cDNA sequences reveals a strong identity in the sequences localized outside the seven highly conserved zinc-finger motifs. The divergence from their common ancestor results in the loss of a potential transcription activator domain in mouse MOK2 protein.

Url:

https://api.istex.fr/ark:/67375/1BB-D3HLQ475-S/fulltext.pdf

DOI: 10.1007/BF00173158

Affiliations:

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ISTEX:CE4CFD3539F638C3DCAAB09B6CAAA5B7EB564D41

Le document en format XML

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<term>Blot</term>
<term>Cdna</term>
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<front><div type="abstract" xml:lang="en">Abstract: We have isolated the human homologue of Mok2 gene encoding a Kriippel-like protein. The identification of three cDNAs and genomic clones reveals that the human protein shows substantial structural differences with the mouse MOK2 protein. The mouse MOK2 protein is composed of seven tandem zinc-finger motifs with five additional amino acids at the COOH-terminal. This structural feature is also present at the end of the human MOK2 protein. The seven zinc-finger motifs show 94% identity between the two proteins. In addition, the human protein contains three additional zinc-finger motifs in tandem with the others and a nonfinger acidic domain of 173 amino acids at the NH2-terminal. The Southern analysis indicates that a single copy of these two genes is present in the genome. The human gene has been localized on chromosome 19 on band q13.2–q13.3. The comparison of human and mouse cDNA sequences reveals a strong identity in the sequences localized outside the seven highly conserved zinc-finger motifs. The divergence from their common ancestor results in the loss of a potential transcription activator domain in mouse MOK2 protein.</div>
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Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins

Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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